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    Applications of comparative evolution to human disease genetics.
    Sep 04, 2015
    Current Opinion In Genetics & Development
    McWhite CD, Liebeskind BJ, Marcotte EM
    Direct comparison of human diseases with model phenotypes allows exploration of key areas of human biology which are often inaccessible for practical or ethical reasons. We review recent developments in comparative evolutionary approaches for finding models for genetic disease, including high-throughput generation of gene/phenotype relationship data, the linking of orthologous genes and phenotypes across species, and statistical methods for linking human diseases to model phenotypes.
      
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